Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists
CIHR| unidentified ,
NIH| Rational discovery of new DOR chemotypes to prevent addiction and overdose ,
NIH| Structure-Function of Opioid Receptors ,
NIH| Opioid Receptor Protein Production Core
Authors: Tobias Claff; Jing Yu; Véronique Blais; Nilkanth Patel; Charlotte Martin; Lijie Wu; Gye Won Han; +12 Authors
Tobias Claff; Jing Yu; Véronique Blais; Nilkanth Patel; Charlotte Martin; Lijie Wu; Gye Won Han; Brian J. Holleran; Olivier Van der Poorten; Kate L. White; Michael A. Hanson; Philippe Sarret; Louis Gendron; Vadim Cherezov; Vsevolod Katritch; Steven Ballet; Zhi-Jie Liu; Christa E. Müller; Raymond C. Stevens;
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists
Abstract
Crystal structures provide first atomic-level insights into δ-opioid receptor activation by two structurally diverse agonists.
Related Organizations
- Vrije Universiteit Brussel Belgium
- University of Bonn Germany
- University of Chinese Academy of Sciences China (People's Republic of)
- University of California System United States
- University of Shanghai for Science and Technology China (People's Republic of)
Keywords
Receptors, Opioid, mu, Spodoptera, Crystallography, X-Ray, Molecular Docking Simulation, Protein Domains, Receptors, Opioid, delta, Sf9 Cells, Animals, Humans, Peptides, Research Articles
Receptors, Opioid, mu, Spodoptera, Crystallography, X-Ray, Molecular Docking Simulation, Protein Domains, Receptors, Opioid, delta, Sf9 Cells, Animals, Humans, Peptides, Research Articles
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).108 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
popularity
Popularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
108
Top 1%
Top 10%
Top 1%
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