The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule inDrosophila
Copyright policy )The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule inDrosophila
A previous genetic screen led to the identification of the beaten path (beat Ia) gene in Drosophila. Beat Ia contains two immunoglobulin (Ig) domains and appears to function as an anti-adhesive factor secreted by specific growth cones to promote axon defasciculation. We identify a family of 14 beat-like genes in Drosophila. In contrast to beat Ia, four novel Beat-family genes encode membrane-bound proteins. Moreover, mutations in each gene lead to much more subtle guidance phenotypes than observed in beat Ia. Genetic interactions between beat Ic and beat Ia reveal complementary functions. Our data suggest a model whereby Beat Ic (and perhaps other membrane-bound family members) functions in a pro-adhesive fashion to regulate fasciculation, while Beat Ia (the original secreted Beat) functions in an anti-adhesive fashion to regulate defasciculation.
- Howard Hughes Medical Institute United States
- University of California, Berkeley United States
Motor Neurons, Sequence Homology, Amino Acid, Molecular Sequence Data, Immunoglobulins, Genes, Insect, Nerve Tissue Proteins, Axons, Evolution, Molecular, Phenotype, Multigene Family, Mutation, Cell Adhesion, Animals, Drosophila Proteins, Drosophila, Amino Acid Sequence, Cell Adhesion Molecules, Phylogeny
Motor Neurons, Sequence Homology, Amino Acid, Molecular Sequence Data, Immunoglobulins, Genes, Insect, Nerve Tissue Proteins, Axons, Evolution, Molecular, Phenotype, Multigene Family, Mutation, Cell Adhesion, Animals, Drosophila Proteins, Drosophila, Amino Acid Sequence, Cell Adhesion Molecules, Phylogeny
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