HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes
Copyright policy )HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes
Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS).To identify genetic risk factors for Hu-PNS and investigate the role of T cells.HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC).The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in HC.This study indicates an association between Hu-PNS and presence of HLA-DQ2 and HLA-DR3, which supports a role for CD4(+) T cells in the pathogenesis of Hu-PNS.
- Erasmus University Rotterdam Netherlands
- French Institute of Health and Medical Research France
- Leiden University Medical Center Netherlands
- University of Lyon System France
Adult, Aged, 80 and over, Male, T-Lymphocytes, Middle Aged, Small Cell Lung Carcinoma, EMC MM-03-44-06, Antibodies, Young Adult, SDG 3 - Good Health and Well-being, ELAV Proteins, HLA-DQ Antigens, CD4 Antigens, Confidence Intervals, Odds Ratio, Humans, Female, EMC MM-03-86-01, Aged, Paraneoplastic Syndromes, Nervous System
Adult, Aged, 80 and over, Male, T-Lymphocytes, Middle Aged, Small Cell Lung Carcinoma, EMC MM-03-44-06, Antibodies, Young Adult, SDG 3 - Good Health and Well-being, ELAV Proteins, HLA-DQ Antigens, CD4 Antigens, Confidence Intervals, Odds Ratio, Humans, Female, EMC MM-03-86-01, Aged, Paraneoplastic Syndromes, Nervous System
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