Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis
Copyright policy )Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis
Mutations in WNT effector genes perturb hair follicle morphogenesis, suggesting key roles for WNT proteins in this process. We show that expression of Wnts 10b and 10a is upregulated in placodes at the onset of follicle morphogenesis and in postnatal hair follicles beginning a new cycle of hair growth. The expression of additional Wnt genes is observed in follicles at later stages of differentiation. Among these, we find that Wnt5a is expressed in the developing dermal condensate of wild type but not Sonic hedgehog (Shh)-null embryos, indicating that Wnt5a is a target of SHH in hair follicle morphogenesis. These results identify candidates for several key follicular signals and suggest that WNT and SHH signaling pathways interact to regulate hair follicle morphogenesis.
- University of Pennsylvania United States
Embryonic Induction, Embryology, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Gene Expression Regulation, Developmental, Nerve Tissue Proteins, Wnt-5a Protein, Up-Regulation, Wnt Proteins, Mice, Proto-Oncogene Proteins, Mutation, Morphogenesis, Trans-Activators, Animals, Hedgehog Proteins, Hair Follicle, In Situ Hybridization, Developmental Biology, Signal Transduction, Skin
Embryonic Induction, Embryology, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Gene Expression Regulation, Developmental, Nerve Tissue Proteins, Wnt-5a Protein, Up-Regulation, Wnt Proteins, Mice, Proto-Oncogene Proteins, Mutation, Morphogenesis, Trans-Activators, Animals, Hedgehog Proteins, Hair Follicle, In Situ Hybridization, Developmental Biology, Signal Transduction, Skin
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).429 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!