Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity
Copyright policy )Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity
Significance HIV-1 viral protein U (Vpu) facilitates virus release from infected cells by down-regulating and degrading tetherin, a transmembrane protein upregulated by IFN that impedes the detachment of enveloped viruses from infected cells. Here we show that this activity of Vpu protects HIV-infected cells from antibodies that are capable of directing their elimination by antibody-dependent cell-mediated cytotoxicity. A direct implication of these observations is that tetherin serves as a link between innate and adaptive immunity to enhance the susceptibility of virus-infected cells to antibodies. Thus, the antiviral activity of tetherin may be much greater than previously appreciated based on its ability to inhibit virus release in cell culture assays.
- Scripps Research Institute United States
- University of Wisconsin–Madison United States
- University of Wisconsin Hospital and Clinics United States
- UW Carbone Cancer Center United States
- International AIDS Vaccine Initiative United States
Human Immunodeficiency Virus Proteins, Antibody-Dependent Cell Cytotoxicity, Interferon-alpha, HIV Infections, Receptors, Cell Surface, GPI-Linked Proteins, Amino Acid Substitution, Signaling Lymphocytic Activation Molecule Family Member 1, Antigens, CD, Cytoprotection, CD4 Antigens, Humans, RNA Interference, Viral Regulatory and Accessory Proteins, Gene Deletion
Human Immunodeficiency Virus Proteins, Antibody-Dependent Cell Cytotoxicity, Interferon-alpha, HIV Infections, Receptors, Cell Surface, GPI-Linked Proteins, Amino Acid Substitution, Signaling Lymphocytic Activation Molecule Family Member 1, Antigens, CD, Cytoprotection, CD4 Antigens, Humans, RNA Interference, Viral Regulatory and Accessory Proteins, Gene Deletion
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