Increased expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNA in chronic otitis media with cholesteatoma
Copyright policy )Increased expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNA in chronic otitis media with cholesteatoma
The increased expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNAs indicates that these pattern recognition receptors are involved in the pathogenesis of cholesteatoma.Changes in expression of pattern recognition receptors may be associated with immune responses in patients with cholesteatoma. We therefore assessed the levels of expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNAs associated with innate immune responses in patients with cholesteatoma.Cholesteatoma specimens were collected from 23 patients diagnosed with acquired cholesteatoma from August 2010 to July 2012. The posterior auricular skin of each patient was used as control. The levels of expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNA were assessed quantitatively using real-time RT-PCR and correlated with sex, hearing level, the presence of bacteria, and the need for repeat surgery.The levels of expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNAs were significantly higher in cholesteatoma than in control skin samples (p 0.05 each).
- Samsung Changwon Hospital Korea (Republic of)
- Sungkyul University Korea (Republic of)
- Sungkyunkwan University Korea (Republic of)
- Samsung Medical Center Korea (Republic of)
- The Catholic University of Korea Catholic Medical Center Korea (Republic of)
Adult, Male, Membrane Glycoproteins, Adolescent, Cholesteatoma, Middle Ear, Membrane Proteins, Receptors, Cell Surface, Middle Aged, B-Cell CLL-Lymphoma 10 Protein, Minor Histocompatibility Antigens, Otitis Media, Antigens, CD, Humans, Female, Lectins, C-Type, Receptors, Immunologic, Child, Hepatitis A Virus Cellular Receptor 2, Adaptor Proteins, Signal Transducing, Aged
Adult, Male, Membrane Glycoproteins, Adolescent, Cholesteatoma, Middle Ear, Membrane Proteins, Receptors, Cell Surface, Middle Aged, B-Cell CLL-Lymphoma 10 Protein, Minor Histocompatibility Antigens, Otitis Media, Antigens, CD, Humans, Female, Lectins, C-Type, Receptors, Immunologic, Child, Hepatitis A Virus Cellular Receptor 2, Adaptor Proteins, Signal Transducing, Aged
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