Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site
Copyright policy )Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site
Significance A solution to the global AIDS epidemic is to develop a vaccine against HIV. This has been difficult to achieve because the virus mutates rapidly, and the antibodies induced by vaccination would need to recognize many different HIV variants. We have developed a computational framework to design panels of antigens for eliciting broadly neutralizing antibodies (bnAbs) for an HIV vaccine. An important aspect of the method is its use of the gp160 fitness landscape, which measures the ability of the virus to tolerate mutations. Most designed antigens assembled as well-ordered native-like trimers with antigenic properties favorable for vaccine studies. These antigens can be used to make meaningful proposals for immunization schedules, a significant advance in HIV vaccine design.
- French National Centre for Scientific Research France
- University of Strasbourg France
- Institut de Science et d'Ingénierie Supramoléculaires France
- University of Strasbourg France
- Scripps Research Institute United States
AIDS Vaccines, CD4-Positive T-Lymphocytes, Models, Molecular, Protein Conformation, alpha-Helical, Binding Sites, HIV Infections, HIV Antibodies, HIV Envelope Protein gp120, Crystallography, X-Ray, HIV Envelope Protein gp41, HIV Envelope Protein gp160, Epitopes, Mutation, HIV-1, Humans, Protein Conformation, beta-Strand, Amino Acid Sequence, Antigens, Viral, Broadly Neutralizing Antibodies, Protein Binding
AIDS Vaccines, CD4-Positive T-Lymphocytes, Models, Molecular, Protein Conformation, alpha-Helical, Binding Sites, HIV Infections, HIV Antibodies, HIV Envelope Protein gp120, Crystallography, X-Ray, HIV Envelope Protein gp41, HIV Envelope Protein gp160, Epitopes, Mutation, HIV-1, Humans, Protein Conformation, beta-Strand, Amino Acid Sequence, Antigens, Viral, Broadly Neutralizing Antibodies, Protein Binding
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