Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy
Copyright policy )Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy
Modeling SARS-CoV-2 in mice Among the research tools necessary to develop medical interventions to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, high on the list are informative animal models with which to study viral pathogenesis. Gu et al. developed a mouse model in which a SARS-CoV-2 strain was infectious and could cause an inflammatory response and moderate pneumonia. Adaptation of this viral strain in the mouse appeared to be dependent on a critical amino acid change, Asn 501 to Tyr (N501Y), within the receptor-binding domain of the viral spike protein. The new mouse model was used to study neutralizing antibodies and a vaccine candidate against the virus. Science , this issue p. 1603
- PEKING UNION MEDICAL COLLEGE China (People's Republic of)
- Fudan University China (People's Republic of)
- Chinese Academy of Medical Sciences & Peking Union Medical College China (People's Republic of)
- Protein Sciences United States
- State Key Laboratory of Proteomics China (People's Republic of)
Mice, Inbred BALB C, Multidisciplinary, COVID-19 Vaccines, COVID-19, High-Throughput Nucleotide Sequencing, Mice, Transgenic, Peptidyl-Dipeptidase A, Betacoronavirus, Disease Models, Animal, Mice, Immunogenicity, Vaccine, Mutation, Animals, Humans, Female, Angiotensin-Converting Enzyme 2, Coronavirus Infections, Lung Diseases, Interstitial, Lung, Pandemics, Research Articles, Administration, Intranasal
Mice, Inbred BALB C, Multidisciplinary, COVID-19 Vaccines, COVID-19, High-Throughput Nucleotide Sequencing, Mice, Transgenic, Peptidyl-Dipeptidase A, Betacoronavirus, Disease Models, Animal, Mice, Immunogenicity, Vaccine, Mutation, Animals, Humans, Female, Angiotensin-Converting Enzyme 2, Coronavirus Infections, Lung Diseases, Interstitial, Lung, Pandemics, Research Articles, Administration, Intranasal
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