Heme oxygenase-1 promotes tumor progression and metastasis of colorectal carcinoma cells by inhibiting antitumor immunity
Copyright policy )Heme oxygenase-1 promotes tumor progression and metastasis of colorectal carcinoma cells by inhibiting antitumor immunity
Heme oxygenase-1 (HO-1) is upregulated in colorectal carcinoma (CRC) cells. However, the role of HO-1 in the metastatic potential of CRC remains to be elucidated. In this study, we investigated the potential of HO-1 to control the antitumor immunity of CRC. Intercellular adhesion molecule-1 (ICAM-1) plays an important role in the immune surveillance system. Hemin-induced HO-1 expression suppressed the expression of ICAM-1 in human CRC cells. HO-1 regulated ICAM-1 expression via tristetraprolin, an mRNA-binding protein, at the posttranscriptional level in CRC cells. The upregulated HO-1 expression in CRC cells markedly decreased the adhesion of peripheral blood mononuclear lymphocytes (PBMLs) to CRC cells and PBML-mediated cytotoxicity against CRC cells. Production of CXCL10, an effector T cell-recruiting chemokine, was significantly reduced by the increased HO-1 expression. The expression of the CXCL10 receptor, CXCR3, decreased significantly in PBMLs that adhered to CRC cells. HO-1 expression correlated negatively, although nonsignificantly, with ICAM-1 and CXCL10 expression in xenograft tumors. Taken together, our data suggest that HO-1 expression is functionally linked to the mediation of tumor progression and metastasis of CRC cells by inhibiting antitumor immunity.
- Wonkwang University Korea (Republic of)
- Yeungnam University
- Tehran University of Medical Sciences Iran (Islamic Republic of)
- Yeungnam University Korea (Republic of)
- College of Pharmacy Iraq
Cytotoxicity, Immunologic, Male, Mice, Inbred BALB C, Intercellular Adhesion Molecule-1, Coculture Techniques, Gene Expression Regulation, Enzymologic, Chemokine CXCL10, Gene Expression Regulation, Neoplastic, Chemotaxis, Leukocyte, Cell Adhesion, Disease Progression, Animals, Humans, RNA Interference, Lymphocytes, Caco-2 Cells, Neoplasm Metastasis, Colorectal Neoplasms, HT29 Cells, Heme Oxygenase-1
Cytotoxicity, Immunologic, Male, Mice, Inbred BALB C, Intercellular Adhesion Molecule-1, Coculture Techniques, Gene Expression Regulation, Enzymologic, Chemokine CXCL10, Gene Expression Regulation, Neoplastic, Chemotaxis, Leukocyte, Cell Adhesion, Disease Progression, Animals, Humans, RNA Interference, Lymphocytes, Caco-2 Cells, Neoplasm Metastasis, Colorectal Neoplasms, HT29 Cells, Heme Oxygenase-1
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