Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development
Copyright policy )Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development
AbstractThe loss of Cecr2, which encodes a chromatin remodeling protein, has been associated with the neural tube defect (NTD) exencephaly and open eyelids in mice. Here, we show that two independent mutations of Cecr2 are also associated with specific inner ear defects. Homozygous mutant 18.5 days post coitus (dpc) fetuses exhibited smaller cochleae as well as rotational defects of sensory cells and extra cell rows in the inner ear reminiscent of planar cell polarity (PCP) mutants. Cecr2 was expressed in the neuroepithelium, head mesenchyme, and the cochlear floor. Although limited genetic interaction for NTDs was seen with Vangl2, a microarray analysis of PCP genes did not reveal a direct connection to this pathway. The mechanism of Cecr2 action in neurogenesis and inner ear development is likely complex. Developmental Dynamics 240:372–383, 2011. © 2011 Wiley‐Liss, Inc.
- University of Alberta Canada
Male, Mice, Inbred BALB C, Organogenesis, Neuroepithelial Cells, Cell Polarity, Nerve Tissue Proteins, Embryo, Mammalian, Microarray Analysis, Chromatin, Mesoderm, Mice, Inbred C57BL, Mice, Ear, Inner, Mutation, Animals, Humans, Intercellular Signaling Peptides and Proteins, Female, Neural Tube Defects, Neurulation
Male, Mice, Inbred BALB C, Organogenesis, Neuroepithelial Cells, Cell Polarity, Nerve Tissue Proteins, Embryo, Mammalian, Microarray Analysis, Chromatin, Mesoderm, Mice, Inbred C57BL, Mice, Ear, Inner, Mutation, Animals, Humans, Intercellular Signaling Peptides and Proteins, Female, Neural Tube Defects, Neurulation
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