KIT's ship comes in
Copyright policy ) Benjamin S, Braun;
KIT's ship comes in
Mali et al demonstrate in this issue of Blood that oncogenic KIT alleles can be attacked through their reliance on signaling through the phosphatase SHP2.1 The importance of aberrant signal transduction in leukemia has long been appreciated. This insight is finally having impact in the clinic, when appropriate tyrosine kinase inhibitors (TKIs) are available.
- University of California, San Francisco United States
Proto-Oncogene Proteins c-kit, Cell Transformation, Neoplastic, Myeloproliferative Disorders, Mutation, Animals, Humans, Protein Tyrosine Phosphatase, Non-Receptor Type 11, GRB2 Adaptor Protein
Proto-Oncogene Proteins c-kit, Cell Transformation, Neoplastic, Myeloproliferative Disorders, Mutation, Animals, Humans, Protein Tyrosine Phosphatase, Non-Receptor Type 11, GRB2 Adaptor Protein
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 0
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Cancer Research