Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism
Copyright policy )Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism
Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of THA (aseptic loosening).The rs5854 single nucleotide polymorphism (SNP) in MMP-1 gene was genotyped in 63 subjects who were diagnosed as aseptic loosening after total hip arthroplasty within 10 years and in 81 age and gender matched controls.The genotype frequencies of the MMP-1 rs5854 C/T polymorphism were 57.1% (CC), 28.6% (CT), and 14.3% (TT) in patients with failure of THA, and 79.0% (CC), 17.3% (CT), and 3.7% (TT) in the controls (P=0.0099). Rs5854 polymorphism was found to be significantly associated with increased risk of aseptic loosening.The results showed the rs5854 SNP was associated with increased risk of the early aseptic loosening susceptibility.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_177.
- Central South University China (People's Republic of)
- University of South China China (People's Republic of)
- First Affiliated Hospital of University of South China China (People's Republic of)
Aged, 80 and over, Male, China, Histology, Genotype, Research, Arthroplasty, Replacement, Hip, Middle Aged, Polymorphism, Single Nucleotide, Pathology and Forensic Medicine, Prosthesis Failure, Asian People, Risk Factors, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Hip Prosthesis, Treatment Failure, Matrix Metalloproteinase 1, Alleles, Aged
Aged, 80 and over, Male, China, Histology, Genotype, Research, Arthroplasty, Replacement, Hip, Middle Aged, Polymorphism, Single Nucleotide, Pathology and Forensic Medicine, Prosthesis Failure, Asian People, Risk Factors, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Hip Prosthesis, Treatment Failure, Matrix Metalloproteinase 1, Alleles, Aged
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