miRNA-218 contributes to the regulation of D-glucuronyl C5-epimerase expression in normal and tumor breast tissues
Copyright policy )miRNA-218 contributes to the regulation of D-glucuronyl C5-epimerase expression in normal and tumor breast tissues
microRNAs (miRNAs) are key posttranscriptional regulators of gene expression. In the present study, regulation of tumor-suppressor gene D-glucuronyl C5-epimerase (GLCE) by miRNA-218 was investigated. Significant downregulation of miRNA-218 expression was shown in primary breast tumors. Exogenous miRNA-218/anti-miRNA-218 did not affect GLCE mRNA but regulated GLCE protein level in MCF7 breast carcinoma cells in vitro. Comparative analysis showed a positive correlation between miRNA-218 and GLCE mRNA, and negative correlation between miRNA-218 and GLCE protein levels in breast tissues and primary tumors in vivo, supporting a direct involvement of miRNA-218 in posttranscriptional regulation of GLCE in human breast tissue. A common scheme for the regulation of GLCE expression in normal and tumor breast tissues is suggested.
- Russian Academy
- Department of Medical Sciences Russian Federation
- Karolinska Institute Sweden
- Institute of Molecular Biology and Biophysics Russian Federation
- National Academy of Sciences of Ukraine Ukraine
GLCE, Brief Report, D-glucuronyl C5-epimerase, Breast Neoplasms, Gene Expression Regulation, Neoplastic, MicroRNAs, breast cancer, Teknik och teknologier, tumor-suppressor gene, expression, MCF-7 Cells, Engineering and Technology, Humans, Female, RNA, Messenger, biosynthesis, heparan sulphate proteoglycan, Carbohydrate Epimerases, miRNA
GLCE, Brief Report, D-glucuronyl C5-epimerase, Breast Neoplasms, Gene Expression Regulation, Neoplastic, MicroRNAs, breast cancer, Teknik och teknologier, tumor-suppressor gene, expression, MCF-7 Cells, Engineering and Technology, Humans, Female, RNA, Messenger, biosynthesis, heparan sulphate proteoglycan, Carbohydrate Epimerases, miRNA
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