The protocadherin-α family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse
Copyright policy )The protocadherin-α family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse
Olfactory sensory neurons (OSNs) that express the same odorant receptor project their axons to specific glomeruli in the main olfactory bulb. Protocadherin-alpha (Pcdha) proteins, diverse cadherin-related molecules that are encoded as a gene cluster, are highly concentrated in OSN axons and olfactory glomeruli. Here, we describe Pcdha mutant mice, in which the constant region of the Pcdha gene cluster has been deleted by gene targeting. The mutant mice show abnormal sorting of OSN axons into glomeruli. There are multiple, small, extraneous glomeruli for the odorant receptors M71 and MOR23. These abnormal patterns of M71 and MOR23 glomeruli persist until adulthood. Many M71 glomeruli, but apparently not MOR23 glomeruli, are heterogeneous in axonal innervation. Thus, Pcdha molecules are involved in coalescence of OSN axons into OR-specific glomeruli of the olfactory bulb.
- Osaka University Japan
- Rockefeller University United States
- Japan Science and Technology Agency Japan
- Fukuoka Women's University Japan
Male, Mice, Inbred ICR, Mice, Transgenic, Receptors, Cell Surface, Olfactory Pathways, Cadherins, Receptors, Odorant, Olfactory Bulb, Axons, Mice, Mutant Strains, Olfactory Receptor Neurons, Mice, Inbred C57BL, Mice, Multigene Family, Gene Targeting, Animals, Gene Deletion
Male, Mice, Inbred ICR, Mice, Transgenic, Receptors, Cell Surface, Olfactory Pathways, Cadherins, Receptors, Odorant, Olfactory Bulb, Axons, Mice, Mutant Strains, Olfactory Receptor Neurons, Mice, Inbred C57BL, Mice, Multigene Family, Gene Targeting, Animals, Gene Deletion
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).117 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!