A mouse homologue of FAST-1 transduces TGFβ superfamily signals and is expressed during early embryogenesis
Copyright policy )A mouse homologue of FAST-1 transduces TGFβ superfamily signals and is expressed during early embryogenesis
The transcription factor FAST-1 has recently been shown to play a key role in the specification of mesoderm by TGF beta superfamily signals in the early Xenopus embryo. We have cloned Fast1, a mouse homologue of Xenopus FAST-1, and characterized its expression during embryogenesis and function in activin/TGF beta signal transduction. In vitro, Fast1 associates with Smads in response to an activin/TGF beta signal to form a complex that recognizes the Xenopus activin responsive element (ARE) targeted by Xenopus FAST-1. In intact cells, introduction of Fast1 confers activin/TGF beta regulation of an ARE-luciferase reporter. In embryos, Fast1 is expressed predominantly throughout the epiblast before gastrulation and declines as development progresses. We propose that mouse Fast1, like Xenopus FAST-1, mediates TGF beta superfamily signals specifying developmental fate during early embryogenesis.
- Vanderbilt University Medical Center United States
- Harvard University United States
Embryology, Sequence Homology, Amino Acid, Transcription, Genetic, Xenopus, Gene Expression Regulation, Developmental, Forkhead Transcription Factors, Smad Proteins, Gastrula, Smad2 Protein, DNA-Binding Proteins, Mice, Transforming Growth Factor beta, Trans-Activators, Animals, Humans, Nerve Growth Factors, Smad3 Protein, Cloning, Molecular, Developmental Biology, Signal Transduction, Smad4 Protein, Transcription Factors
Embryology, Sequence Homology, Amino Acid, Transcription, Genetic, Xenopus, Gene Expression Regulation, Developmental, Forkhead Transcription Factors, Smad Proteins, Gastrula, Smad2 Protein, DNA-Binding Proteins, Mice, Transforming Growth Factor beta, Trans-Activators, Animals, Humans, Nerve Growth Factors, Smad3 Protein, Cloning, Molecular, Developmental Biology, Signal Transduction, Smad4 Protein, Transcription Factors
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