Structural topology defines protective CD8 + T cell epitopes in the HIV proteome
Copyright policy )Structural topology defines protective CD8 + T cell epitopes in the HIV proteome
Structure-based immunogen design Vaccine design for highly mutable pathogens is hindered by a paucity of conserved immunogenic epitopes. Gaiha et al. employed a structure-based technique using network theory to assign scores to protein structure in order to infer mutational constraints (see the Perspective by McMichael and Carrington). The authors validated the method on proteins with published functional outcomes and then assessed mutational constraints within the HIV proteome. Highly networked residues strongly associated with immune control of HIV infection and may lead to protective immunogens for pathogens for which there is currently no efficient vaccine. Science , this issue p. 480 ; see also p. 438
- Massachusetts Institute of Technology United States
- Broad Institute United States
- Massachusetts General Hospital United States
- Howard Hughes Medical Institute United States
- Ragon Institute of MGH, MIT and Harvard United States
AIDS Vaccines, Acquired Immunodeficiency Syndrome, Proteome, Histocompatibility Antigens Class I, Epitopes, T-Lymphocyte, CD8-Positive T-Lymphocytes, Virus Replication, gag Gene Products, Human Immunodeficiency Virus, HLA-B Antigens, Mutation, HIV-1, Humans, Alleles, Conserved Sequence
AIDS Vaccines, Acquired Immunodeficiency Syndrome, Proteome, Histocompatibility Antigens Class I, Epitopes, T-Lymphocyte, CD8-Positive T-Lymphocytes, Virus Replication, gag Gene Products, Human Immunodeficiency Virus, HLA-B Antigens, Mutation, HIV-1, Humans, Alleles, Conserved Sequence
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).126 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!