STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential
Copyright policy )STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential
Serine/threonine kinase 33 (STK33) is a novel protein that has attracted considerable interest in recent years. Previous research has revealed that STK33 expression plays a special role in cancer cell proliferation. However, the mechanisms of STK33 induction of cancer cells remain largely unknown. In this study, it is demonstrated that STK33 expression varies in NL9980 and L9981 cells which are homogeneous cell lines with similar genetic backgrounds. STK33 can promote cell migration and invasion and suppress p53 gene expression in the NL9980 and L9981 cells. In addition, this protein also promotes epithelial-mesenchymal transition (EMT). Moreover, STK33 knockdown decreases tumor-related gene expression and inhibits cell migration, invasion, and EMT, suggesting that STK33 may be a mediator of signaling pathways that are involved in cancer. In conclusion, our results suggest that STK33 may be an important prognostic marker and a therapeutic target for the metastatic progression of human lung cancer.
- First People's Hospital of Yunnan Province China (People's Republic of)
Integrins, Receptors, CXCR4, Epithelial-Mesenchymal Transition, Lung Neoplasms, Gene Expression, Protein Serine-Threonine Kinases, Genes, p53, Prognosis, Cyclin-Dependent Kinases, Cell Movement, Cell Line, Tumor, Gene Knockdown Techniques, CDC2 Protein Kinase, Biomarkers, Tumor, Carcinoma, Large Cell, Humans, Neoplasm Invasiveness, Signal Transduction
Integrins, Receptors, CXCR4, Epithelial-Mesenchymal Transition, Lung Neoplasms, Gene Expression, Protein Serine-Threonine Kinases, Genes, p53, Prognosis, Cyclin-Dependent Kinases, Cell Movement, Cell Line, Tumor, Gene Knockdown Techniques, CDC2 Protein Kinase, Biomarkers, Tumor, Carcinoma, Large Cell, Humans, Neoplasm Invasiveness, Signal Transduction
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