Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy
Copyright policy )Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy
Key Points Restricting transgenic antigen expression to differentiated antigen-presenting cells protects hematopoietic progenitors from immune attack. Restricting transgenic antigen expression to differentiated antigen-presenting cells promotes tolerogenic outcomes.
- University of Queensland Australia
- University of Queensland Australia
- University of Queensland Australia
- QIMR Berghofer Medical Research Institute Australia
570, 1303 Biochemistry, Transplantation Conditioning, Ovalbumin, T-Lymphocytes, 2720 Hematology, 610, Antigen-Presenting Cells, Mice, Transgenic, 1307 Cell Biology, Mice, Immune Tolerance, Animals, Bone Marrow Transplantation, 2403 Immunology, Analysis of Variance, Mice, Inbred BALB C, Stem Cells, Hematopoietic Stem Cell Transplantation, Histocompatibility Antigens Class II, Cell Differentiation, Hematology, Dendritic Cells, Flow Cytometry, CD11c Antigen, Mice, Inbred C57BL
570, 1303 Biochemistry, Transplantation Conditioning, Ovalbumin, T-Lymphocytes, 2720 Hematology, 610, Antigen-Presenting Cells, Mice, Transgenic, 1307 Cell Biology, Mice, Immune Tolerance, Animals, Bone Marrow Transplantation, 2403 Immunology, Analysis of Variance, Mice, Inbred BALB C, Stem Cells, Hematopoietic Stem Cell Transplantation, Histocompatibility Antigens Class II, Cell Differentiation, Hematology, Dendritic Cells, Flow Cytometry, CD11c Antigen, Mice, Inbred C57BL
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