The effects of gene polymorphisms in angiotensin II receptors on pregnancy-induced hypertension and preeclampsia: a systematic review and meta-analysis
Copyright policy )The effects of gene polymorphisms in angiotensin II receptors on pregnancy-induced hypertension and preeclampsia: a systematic review and meta-analysis
To assess whether the polymorphisms of angiotensin II type 1 and type 2 receptors (AT1R, AT2R) are associated with pregnancy-induced hypertension (PIH) and preeclampsia.Studies were searched from PubMed, ISI Web of Science and HuGE Navigator.The A1166C polymorphism of AT1R, A1675G and C3123A polymorphisms of AT2R were analyzed. Significant association was found in recessive model (OR = 1.581, 95% confidence interval (CI): 1.054-2.371) and co-dominant (GG versus AG) model (OR = 1.900, 95%CI: 1.001-3.604) between the A1675G polymorphism and preeclampsia. No association was found between the other polymorphisms and PIH or preeclampsia.The A1675G polymorphism might be associated with preeclampsia, but the A1166C and C3123A polymorphisms had no effect on PIH or preeclampsia.
- Huazhong University of Science and Technology China (People's Republic of)
Pre-Eclampsia, Pregnancy, Confidence Intervals, Humans, Female, Hypertension, Pregnancy-Induced, Polymorphism, Single Nucleotide, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1
Pre-Eclampsia, Pregnancy, Confidence Intervals, Humans, Female, Hypertension, Pregnancy-Induced, Polymorphism, Single Nucleotide, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).16 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!