Crx, a Novel otx-like Homeobox Gene, Shows Photoreceptor-Specific Expression and Regulates Photoreceptor Differentiation
Copyright policy )Crx, a Novel otx-like Homeobox Gene, Shows Photoreceptor-Specific Expression and Regulates Photoreceptor Differentiation
We have isolated a novel otx-like homeobox gene, Crx, from the mouse retina. Crx expression is restricted to developing and mature photoreceptor cells. CRX bound and transactivated the sequence TAATCC/A, which is found upstream of several photoreceptor-specific genes, including the opsin genes from many species. Overexpression of Crx using a retroviral vector increased the frequency of clones containing exclusively rod photoreceptors and reduced the frequency of clones containing amacrine interneurons and Müller glial cells. In addition, presumptive photoreceptor cells expressing a dominant-negative form of CRX failed to form proper photoreceptor outer segments and terminals. Crx is a novel photoreceptor-specific transcription factor and plays a crucial role in the differentiation of photoreceptor cells.
- Howard Hughes Medical Institute United States
- Harvard University United States
Homeodomain Proteins, Otx Transcription Factors, Biochemistry, Genetics and Molecular Biology(all), Genetic Vectors, Molecular Sequence Data, Genes, Homeobox, Gene Expression Regulation, Developmental, Cell Differentiation, Nerve Tissue Proteins, 3T3 Cells, DNA, Peptide Fragments, Mice, Interneurons, Organ Specificity, Animals, Photoreceptor Cells, Amino Acid Sequence, Cloning, Molecular, Moloney murine leukemia virus, Neuroglia
Homeodomain Proteins, Otx Transcription Factors, Biochemistry, Genetics and Molecular Biology(all), Genetic Vectors, Molecular Sequence Data, Genes, Homeobox, Gene Expression Regulation, Developmental, Cell Differentiation, Nerve Tissue Proteins, 3T3 Cells, DNA, Peptide Fragments, Mice, Interneurons, Organ Specificity, Animals, Photoreceptor Cells, Amino Acid Sequence, Cloning, Molecular, Moloney murine leukemia virus, Neuroglia
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