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Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2009 English Publisher:Elsevier BVJournal:Journal of Neuroimmunology, volume 210, pages 108-112 (issn: 0165-5728,

Authors: Louise A. Hurst; Babette B. Weksler; Pierre-Olivier Couraud; Pierre-Olivier Couraud; Rowena A.D. Bunning; Basil Sharrack; Ignacio A. Romero; +1 Authors

doi: 10.1016/j.jneuroim.2009.02.008

pmid: 19324423

Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment

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Abstract

ADAM-17 expression is localised to endothelial cells in the human central nervous system (CNS) and is increased in multiple sclerosis (MS) white matter, suggesting a role in MS pathogenesis. Expression of ADAM-17, TIMP-3, and fractalkine were investigated in a human brain endothelial cell line (hCMEC/D3) after pro-inflammatory cytokine treatment. Tumour necrosis factor (TNF) significantly increased fractalkine mRNA (>100 fold) and protein expression, which was associated with increased shedding of fractalkine from the cell. Fractalkine shedding may regulate immune cell trafficking into the CNS, however, this does not appear to be directly controlled by ADAM-17 activity.

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Keywords

Tissue Inhibitor of Metalloproteinase-3, Chemokine CX3CL1, Tumor Necrosis Factor-alpha, Endothelial Cells, Gene Expression, ADAM17 Protein, Cell Line, Up-Regulation, ADAM Proteins, Chemotaxis, Leukocyte, Cytokines, Encephalitis, Humans, RNA, Messenger

14 Research products, page 1 of 2

Chemokine (C-X3-C motif) ligand 1 variant
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cDNA, FLJ94424, Homo sapiens chemokine (C-X3-C motif) ligand 1 (CX3CL1), mRNA
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Disintegrin and metalloproteinase domain-containing protein 17
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cDNA FLJ77013, highly similar to Homo sapiens ADAM metallopeptidase domain 17 (tumor necrosis factor
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Uncharacterized protein ADAM17
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ADAM17 protein
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ADAM metallopeptidase domain 17 (Tumor necrosis factor, alpha, converting enzyme), isoform CRA_b
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Uncharacterized protein ADAM17
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ADAM17 protein
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Chemokine (C-X3-C motif) ligand 1 variant
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