The c.469+46_56del mutation in the homeobox MSX1 gene—A novel risk factor in breast cancer?
Copyright policy )The c.469+46_56del mutation in the homeobox MSX1 gene—A novel risk factor in breast cancer?
The aim of this study was to investigate the association of a 11 nucleotide deletion, the c.469+46_56del mutation, in the intron of the homeobox MSX1 gene and breast cancer occurrence and characteristics.The mutation was genotyped in peripheral blood lymphocytes of 200 breast cancer patients and 203 controls by single-strand conformational PCR and DNA sequencing.The del/del variant of the c.469+46_56del mutation increased the risk of breast cancer occurrence (OR 2.20; 95% CI 1.41-3.44, p<0.05). We did not observe any association between genotypes of this mutation and lymph node status, Bloom-Richardson grading, estrogen and progesterone receptors and HER2 expression.The del/del genotype of the c.469+46_56del mutation in the MSX1 gene may be associated with the increased risk of breast cancer in Polish population and may be considered as an early marker in this disease.
- University of Łódź Poland
Adult, Aged, 80 and over, MSX1 Transcription Factor, Base Sequence, Molecular Sequence Data, Breast Neoplasms, Middle Aged, Polymerase Chain Reaction, Humans, Female, Genetic Predisposition to Disease, Polymorphism, Single-Stranded Conformational, Aged, Sequence Deletion
Adult, Aged, 80 and over, MSX1 Transcription Factor, Base Sequence, Molecular Sequence Data, Breast Neoplasms, Middle Aged, Polymerase Chain Reaction, Humans, Female, Genetic Predisposition to Disease, Polymorphism, Single-Stranded Conformational, Aged, Sequence Deletion
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).10 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!