Whole-Genome Analysis of Dorsal-Ventral Patterning in the Drosophila Embryo
Copyright policy )Whole-Genome Analysis of Dorsal-Ventral Patterning in the Drosophila Embryo
The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tissue-specific form of the NF-Y transcription complex is essential for the activation of gene expression in the mesoderm. Tissue-specific enhancers were identified for new Dorsal target genes, and bioinformatics methods identified conserved cis-regulatory elements for coordinately regulated genes that respond to similar thresholds of the Dorsal gradient. The new Dorsal target genes and enhancers represent one of the most extensive gene networks known for any developmental process.
- California Institute of Technology United States
- University of California, Berkeley United States
- University of Chicago United States
- University of Massachusetts Amherst United States
- UNIVERSITY OF CALIFORNIA BERKELEY
Male, 570, Transcription and Gene Expression, Bioinformatics, Molecular Sequence Data, cis-regulation, embryo, Embryonic Development, Mesoderm, Dorsal, Animals, Drosophila Proteins, NF-kB, Transgenes, Biology, Conserved Sequence, Body Patterning, Oligonucleotide Array Sequence Analysis, patterning, Genome, Models, Genetic, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Regulation, Developmental, CCAAT-Binding Factor, Drosophila, Female
Male, 570, Transcription and Gene Expression, Bioinformatics, Molecular Sequence Data, cis-regulation, embryo, Embryonic Development, Mesoderm, Dorsal, Animals, Drosophila Proteins, NF-kB, Transgenes, Biology, Conserved Sequence, Body Patterning, Oligonucleotide Array Sequence Analysis, patterning, Genome, Models, Genetic, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Regulation, Developmental, CCAAT-Binding Factor, Drosophila, Female
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