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Blood
Article
Data sources: UnpayWall
Blood
Article . 2014 . Peer-reviewed
Data sources: Crossref
Blood
Article . 2014
Data sources: Europe PubMed Central
https://dx.doi.org/10.1182/blo...
Article
Data sources: Microsoft Academic Graph
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CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma

descriptionPublicationkeyboard_double_arrow_right Article 12 Jun 2014 English Publisher:American Society of HematologyJournal:Blood, volume 123, pages 3,770-3,779 (issn: 0006-4971, eissn: 1528-0020, Copyright policy )
Authors: Megan E. Murray; Catherine M. Gavile; Jayakumar R. Nair; Chandana Koorella; Louise M. Carlson; Daniela Buac; Adam Utley; +4 Authors

doi: 10.1182/blood-2013-10-530964

pmid: 24782505

pmc: PMC4055924

CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma

Abstract

Key PointsCD28 delivers a pro-survival signal to MM cells via regulation of PI3K/Akt, FoxO3a, and Bim. Blockade of CD28:CD80/CD86 in vivo resensitizes MM cells to chemotherapy and significantly reduces tumor burden.

Related Organizations
Keywords

Cell Survival, Antineoplastic Agents, Mice, Transgenic, Dendritic Cells, Antibodies, Mice, Phosphatidylinositol 3-Kinases, CD28 Antigens, Drug Resistance, Neoplasm, Animals, Humans, Multiple Myeloma, Proto-Oncogene Proteins c-akt, Cells, Cultured, Signal Transduction

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 80
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
80
Top 10%
Top 10%
Top 10%
bronze
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