The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells
Copyright policy )The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells
Gfi1 plays an important role in the development and maintenance of many hematopoietic linage cells. However, the impact of Gfi1-deficiency on the iNKT cell differentiation remains unclear. We herein demonstrate a critical role of Gfi1 in regulating the development of iNKT cell subsets. In the thymus of T cell-specific Gfi1-deficient mice, iNKT cells normally developed up to stage 2, while the number of stage 3 NK1.1pos iNKT cells was significantly reduced. Furthermore, CD4pos iNKT cells were selectively reduced in the peripheral organs of T cell-specific Gfi1-deficient mice. The α-GalCer-dependent production of IFN-γand Th2 cytokines, but not IL-17A, was severely reduced in T cell-specific Gfi1-deficient mice. In addition, a reduction of the α-GalCer-induced anti-tumor activity was observed in Gfi1-deficient mice. These findings demonstrate the important role of Gfi1 in regulating the development and function of NKT1- and NKT2-type iNKT cell subsets.
Lung Neoplasms, Science, Q, R, Melanoma, Experimental, Cell Differentiation, Galactosylceramides, DNA-Binding Proteins, Interferon-gamma, Mice, CD4 Antigens, Medicine, Animals, Antigens, Ly, Cytokines, Natural Killer T-Cells, Gene Knock-In Techniques, Gene Deletion, Research Article, NK Cell Lectin-Like Receptor Subfamily B, Transcription Factors
Lung Neoplasms, Science, Q, R, Melanoma, Experimental, Cell Differentiation, Galactosylceramides, DNA-Binding Proteins, Interferon-gamma, Mice, CD4 Antigens, Medicine, Animals, Antigens, Ly, Cytokines, Natural Killer T-Cells, Gene Knock-In Techniques, Gene Deletion, Research Article, NK Cell Lectin-Like Receptor Subfamily B, Transcription Factors
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