Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1α,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysis
Copyright policy )Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1α,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysis
The nuclear receptor of Vitamin D can be activated by a large number of agonist molecules with a wide spectrum in their stereochemical framework. Up to now most of our structural information related to the protein-ligand complex formation is based on an engineered ligand binding domain (LBD) of the human receptor. We now have extended our database, using a wild-type LBD from zebrafish that confirms the previously reported results and allows to investigate the binding of ligands that induce significant conformational changes at the protein level.
Models, Molecular, Sequence Homology, Amino Acid, Protein Conformation, Molecular Sequence Data, Crystallography, X-Ray, Calcitriol, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Receptors, Calcitriol, Amino Acid Sequence, Zebrafish
Models, Molecular, Sequence Homology, Amino Acid, Protein Conformation, Molecular Sequence Data, Crystallography, X-Ray, Calcitriol, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Receptors, Calcitriol, Amino Acid Sequence, Zebrafish
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).61 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!