Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
Copyright policy )Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-beta (PLC-beta) coupled with guanine-nucleotide-binding G proteins. There are four isoenzymes of PLC-beta, beta1-beta4, but their functions in vivo are not known. Here we investigate the role of PLC-beta1 and PLC-beta4 in the brain by generating null mutations in mice: we found that PLCbeta1-/- mice developed epilepsy and PLCbeta4-/- mice showed ataxia. We determined the molecular basis of these phenotypes and show that PLC-beta1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling predominantly to the muscarinic acetylcholine receptor, whereas PLC-beta4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PLC-beta isoenzymes are used to generate different functions in the brain.
- Pohang University of Science and Technology Korea (Republic of)
- UNIST (Ulsan National Institute of Science and Technology) Korea (Republic of)
- Korea Advanced Institute of Science and Technology Korea (Republic of)
- Inje University Korea (Republic of)
INTERNEURONS, Phospholipase C beta, SIGNAL-TRANSDUCTION, Muscarinic Agonists, RAT-BRAIN, Phosphatidylinositols, Receptors, Metabotropic Glutamate, Hippocampus, Piperazines, Mice, Cerebellum, Animals, Cycloleucine, MESSENGER-RNAS, EPILEPSY, Mice, Knockout, Binding Sites, Epilepsy, PHOSPHOINOSITIDE HYDROLYSIS, Brain, LOCALIZATION, Receptors, Muscarinic, Serotonin Receptor Agonists, ALZHEIMERS-DISEASE, Isoenzymes, MICE, Mutagenesis, SEIZURES, Ataxia, Carbachol
INTERNEURONS, Phospholipase C beta, SIGNAL-TRANSDUCTION, Muscarinic Agonists, RAT-BRAIN, Phosphatidylinositols, Receptors, Metabotropic Glutamate, Hippocampus, Piperazines, Mice, Cerebellum, Animals, Cycloleucine, MESSENGER-RNAS, EPILEPSY, Mice, Knockout, Binding Sites, Epilepsy, PHOSPHOINOSITIDE HYDROLYSIS, Brain, LOCALIZATION, Receptors, Muscarinic, Serotonin Receptor Agonists, ALZHEIMERS-DISEASE, Isoenzymes, MICE, Mutagenesis, SEIZURES, Ataxia, Carbachol
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