Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments
Copyright policy )Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments
Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles.
- University of Bristol United Kingdom
- University of Bristol (UoB) United Kingdom
- MRC Toxicology Unit United Kingdom
- UNIVERSITY OF BRISTOL
- University Of Bristol
DNA Replication, 570, Animal, 610, Herpesvirus 1, Human, Virus Replication, DNA, Viral, Humans, Pol1 Transcription Initiation Complex Proteins, HeLa Cells
DNA Replication, 570, Animal, 610, Herpesvirus 1, Human, Virus Replication, DNA, Viral, Humans, Pol1 Transcription Initiation Complex Proteins, HeLa Cells
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