Reappraisal of the Relationship between the HIV-1-Protective Single-Nucleotide Polymorphism 35 Kilobases Upstream of theHLA-CGene and Surface HLA-C Expression
Copyright policy )Reappraisal of the Relationship between the HIV-1-Protective Single-Nucleotide Polymorphism 35 Kilobases Upstream of theHLA-CGene and Surface HLA-C Expression
ABSTRACTPrevious studies have found an association between a single-nucleotide polymorphism 35 kb upstream of theHLA-Clocus (−35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across −35 SNP genotypes can be attributed primarily to the very low expression of a single allelic product, HLA-Cw7, which is a common HLA type. We suggest that association of the −35 SNP and HIV-1 load manifests as a result of linkage disequilibrium of this polymorphism with both favorable and unfavorable HLA-C and -B alleles.
- University of California, San Francisco United States
- Imperial College London United Kingdom
- University of North Carolina at Chapel Hill United States
- John Radcliffe Hospital United Kingdom
- University of Oxford United Kingdom
HIV-1, Gene Expression, Humans, HLA-C Antigens, Regulatory Elements, Transcriptional, Viral Load, Polymorphism, Single Nucleotide, Linkage Disequilibrium
HIV-1, Gene Expression, Humans, HLA-C Antigens, Regulatory Elements, Transcriptional, Viral Load, Polymorphism, Single Nucleotide, Linkage Disequilibrium
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