Proteolysis and the cell cycle: with this RING I do thee destroy
Copyright policy )Proteolysis and the cell cycle: with this RING I do thee destroy
The ubiquitin system drives the cell division cycle by the timely destruction of numerous regulatory proteins. Remarkably, the two main activities that catalyze substrate ubiquitination in the cell cycle, the Skp1-Cdc53/cullin-F-box protein (SCF) complexes and the anaphase-promoting complex/cyclosome (APC/C), define a new superfamily of E3 ubiquitin ligases, all based on related cullin and RING-H2 finger protein subunits. The circuits that interconnect the SCF, APC/C and cyclin-dependent kinase activities form a master oscillator that coordinates the replication and segregation of the genome.
- University of Toronto Canada
- Mount Sinai Health System United States
- Lunenfeld-Tanenbaum Research Institute Canada
- Mount Sinai Hospital Canada
- Mount Sinai Hospital United States
SKP Cullin F-Box Protein Ligases, Ubiquitin-Protein Ligases, Cell Cycle, Mitosis, Ubiquitin-Protein Ligase Complexes, Zinc Fingers, Anaphase-Promoting Complex-Cyclosome, Cyclin-Dependent Kinases, Genes, cdc, Ligases, Yeasts, Animals, Humans, Peptide Synthases
SKP Cullin F-Box Protein Ligases, Ubiquitin-Protein Ligases, Cell Cycle, Mitosis, Ubiquitin-Protein Ligase Complexes, Zinc Fingers, Anaphase-Promoting Complex-Cyclosome, Cyclin-Dependent Kinases, Genes, cdc, Ligases, Yeasts, Animals, Humans, Peptide Synthases
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).272 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!