ARF1–GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis
Copyright policy )ARF1–GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis
Significance Ras small GTPases including ARFs act as molecular switches to modulate signaling pathways involved in hematopoiesis. Decreased guanine nucleotide exchange factor activity or increased GTPase-activating protein activation are associated with many leukemias, myelodysplastic syndromes, and myeloproliferative disorders. Drosophila is a good model to address questions related to aberrant hematopoiesis. Using Drosophila genetics and gene expression analysis we show tissue-specific function of the ubiquitously expressed endocytic protein, Drosophila ARF1 by interaction of ARF1–GTP with a blood-cell–expressed endocytic protein Asrij. The ARF1–Asrij axis brings about endosomal regulation of multiple signaling pathways in hematopoiesis.
Blood Cells, Hemocytes, Receptors, Notch, Membrane Proteins, Hematopoiesis, Protein Transport, Drosophila melanogaster, Phenotype, Larva, Animals, Drosophila Proteins, Homeostasis, Insulin, Guanosine Triphosphate, Lymph Nodes, Cell Proliferation, Protein Binding, Signal Transduction
Blood Cells, Hemocytes, Receptors, Notch, Membrane Proteins, Hematopoiesis, Protein Transport, Drosophila melanogaster, Phenotype, Larva, Animals, Drosophila Proteins, Homeostasis, Insulin, Guanosine Triphosphate, Lymph Nodes, Cell Proliferation, Protein Binding, Signal Transduction
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