Accelerated actin filament polymerization from microtubule plus ends
Copyright policy )Accelerated actin filament polymerization from microtubule plus ends
Making the fast faster still Coordination between actin and microtubule cytoskeleton dynamics is critical during cell migration, phagocytosis, cytokinesis, and embryogenesis. However, the basis for cross-regulation of cytoskeleton dynamics is unclear. Henty-Ridilla et al. found that a component of the microtubule cytoskeleton accelerates actin filament elongation and protects the growing actin filament end (see the Perspective by Rottner). Thus, growing microtubules appear to be able to directly control the actin assembly machinery and actin filament dynamics. Science , this issue p. 1004 ; see also p. 894
- Brandeis University United States
Fetal Proteins, Neurons, Microfilament Proteins, Formins, Nuclear Proteins, Microtubules, Neoplasm Proteins, Polymerization, Rats, Actin Cytoskeleton, Microscopy, Fluorescence, Animals, Humans, Protein Isoforms, Protein Multimerization, Microtubule-Associated Proteins, Cells, Cultured, Cytoskeleton, Adaptor Proteins, Signal Transducing
Fetal Proteins, Neurons, Microfilament Proteins, Formins, Nuclear Proteins, Microtubules, Neoplasm Proteins, Polymerization, Rats, Actin Cytoskeleton, Microscopy, Fluorescence, Animals, Humans, Protein Isoforms, Protein Multimerization, Microtubule-Associated Proteins, Cells, Cultured, Cytoskeleton, Adaptor Proteins, Signal Transducing
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