Cyclic diarylheptanoids as inhibitors of NO production from Acer nikoense

descriptionPublicationkeyboard_double_arrow_right Article 29 Mar 2012 English Publisher:Springer Science and Business Media LLCJournal:Journal of Natural Medicines, volume 67, pages 234-239 (issn: 1340-3443, eissn: 1861-0293,

Authors: Jun, Deguchi; Yusuke, Motegi; Asami, Nakata; Takahiro, Hosoya; Hiroshi, Morita;

doi: 10.1007/s11418-012-0660-0

pmid: 22456895

Cyclic diarylheptanoids as inhibitors of NO production from Acer nikoense

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Abstract

We prepared a series of acerogenins A and B derivatives as inhibitors of nitric oxide (NO) production in vitro. Our results suggested that an ester group at a hydroxyl at C-2 improved inhibitory effects without cytotoxicity. A benzoyl ester derivative of acerogenin C showed the most potent inhibitory activity of NO production from lipopolysaccharide-activated macrophages.

Related Organizations

Hoshi University
Japan
Tokyo University of Science
Japan

Keywords

Diarylheptanoids, Acer, Nitric Oxide

18 Research products, page 1 of 2

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