IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan
Copyright policy )IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan
Post-kala-azar dermal leishmanaisis (PKDL) in Sudan is associated with elevated interferon-gamma (IFN-gamma). To study interferon-gamma pathways in PKDL, we genotyped 80 trios from the Masalit ethnic group for polymorphisms at -470 ins/delTT, -270T/C, -56T/C and +95T/C in IFNGR1 and at -179G/A and +874T/A in IFNG. No associations occurred at IFNG. Global association with haplotypes comprising all four markers at IFNGR1 (chi(2)(10df)=21.97, P=0.015) was observed, associated with a significant (chi(2)(1df)=4.54, P=0.033) bias in transmission of the haplotype insTT T T T and less (chi(2)(1df)=5.59, P=0.018) than expected transmission of insTT C C C. When compared with data on malaria associations from Gambia, the results suggest a complex pattern of haplotypic variation at the IFNGR1 promoter locus associated with different infectious disease in African populations that reflect the complex roles of IFN-gamma in parasite killing versus inflammation and pathogenesis.
- Cambridge University Hospitals NHS Foundation Trust United Kingdom
- University of Khartoum Sudan
- University of Cambridge United Kingdom
- Addenbrooke's Hospital United Kingdom
Leishmaniasis, Cutaneous, Polymorphism, Single Nucleotide, Sudan, Interferon-gamma, Haplotypes, Humans, Leishmaniasis, Visceral, Genetic Predisposition to Disease, Promoter Regions, Genetic, Receptors, Interferon, Interferon gamma Receptor
Leishmaniasis, Cutaneous, Polymorphism, Single Nucleotide, Sudan, Interferon-gamma, Haplotypes, Humans, Leishmaniasis, Visceral, Genetic Predisposition to Disease, Promoter Regions, Genetic, Receptors, Interferon, Interferon gamma Receptor
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).45 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!