Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes
Copyright policy )Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes
From insects to mammals, metallothionein genes are induced in response to heavy metal load by the transcription factor MTF-1, which binds to short DNA sequence motifs, termed metal response elements (MREs). Here we describe a novel and seemingly paradoxical role for MTF-1 in Drosophila in that it also mediates transcriptional activation of Ctr1B, a copper importer, upon copper depletion. Activation depends on the same type of MRE motifs in the upstream region of the Ctr1B gene as are normally required for metal induction. Thus, a single transcription factor, MTF-1, plays a direct role in both copper detoxification and acquisition by inducing the expression of metallothioneins and of a copper importer, respectively.
- Boston Children's Hospital United States
- Harvard University United States
- Duke University Hospital United States
- University of Zurich Switzerland
- Duke Medical Center United States
Ion Transport, Green Fluorescent Proteins, Computational Biology, Biological Transport, Electrophoretic Mobility Shift Assay, Transfection, Transcription Factor MTF-1, DNA-Binding Proteins, Gene Components, Gene Expression Regulation, Animals, Drosophila, Metallothionein, Cation Transport Proteins, Cells, Cultured, Copper, Copper Transporter 1, Protein Binding, Transcription Factors
Ion Transport, Green Fluorescent Proteins, Computational Biology, Biological Transport, Electrophoretic Mobility Shift Assay, Transfection, Transcription Factor MTF-1, DNA-Binding Proteins, Gene Components, Gene Expression Regulation, Animals, Drosophila, Metallothionein, Cation Transport Proteins, Cells, Cultured, Copper, Copper Transporter 1, Protein Binding, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).144 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!