Increase in Quinolone Resistance in a Haemophilus influenzae Strain Isolated from a Patient with Recurrent Respiratory Infections Treated with Ofloxacin
Copyright policy )Increase in Quinolone Resistance in a Haemophilus influenzae Strain Isolated from a Patient with Recurrent Respiratory Infections Treated with Ofloxacin
ABSTRACT The increase in the level of quinolone resistance of Haemophilus influenzae clinical isolates during ofloxacin therapy of a patient with recurrent respiratory infections was investigated. The first isolate (MIC of ciprofloxacin of 2 μg/ml) and the second isolate (MIC of 32 μg/ml) belonged to the same clone, as shown by pulsed-field gel electrophoresis, and the increase in the resistance level was associated with a substitution in Ser-84 to Arg in the ParC protein. These results emphasize the potential risk of development of quinolone-resistant H. influenzae during fluoroquinolone therapy in patients with recurrent respiratory infection.
- Autonomous University of Barcelona Spain
- Hospital de Sant Pau Spain
- University of Barcelona Spain
DNA Topoisomerase IV, Ofloxacin, Haemophilus Infections, Microbial Sensitivity Tests, Middle Aged, Haemophilus influenzae, Polymerase Chain Reaction, DNA Topoisomerases, Type II, Amino Acid Substitution, Anti-Infective Agents, Recurrence, Mutation, Humans, Female, Respiratory Tract Infections
DNA Topoisomerase IV, Ofloxacin, Haemophilus Infections, Microbial Sensitivity Tests, Middle Aged, Haemophilus influenzae, Polymerase Chain Reaction, DNA Topoisomerases, Type II, Amino Acid Substitution, Anti-Infective Agents, Recurrence, Mutation, Humans, Female, Respiratory Tract Infections
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