The Tudor domain ‘Royal Family’: Tudor, plant Agenet, Chromo, PWWP and MBT domains
Copyright policy )The Tudor domain ‘Royal Family’: Tudor, plant Agenet, Chromo, PWWP and MBT domains
We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.
- Wellcome Trust United Kingdom
- Cancer Research UK United Kingdom
- University of Oxford United Kingdom
- University of Cambridge United Kingdom
- Research Institute of Molecular Pathology Austria
Models, Molecular, Sequence Homology, Amino Acid, Molecular Sequence Data, Arabidopsis, Membrane Transport Proteins, Minisatellite Repeats, Protein Structure, Secondary, Protein Structure, Tertiary, Evolution, Molecular, Animals, Drosophila Proteins, Humans, Insect Proteins, Amino Acid Sequence, Plant Proteins
Models, Molecular, Sequence Homology, Amino Acid, Molecular Sequence Data, Arabidopsis, Membrane Transport Proteins, Minisatellite Repeats, Protein Structure, Secondary, Protein Structure, Tertiary, Evolution, Molecular, Animals, Drosophila Proteins, Humans, Insect Proteins, Amino Acid Sequence, Plant Proteins
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