Molecular characterization of a deletion encompassing the splotch mutation on mouse chromosome 1
Copyright policy )Molecular characterization of a deletion encompassing the splotch mutation on mouse chromosome 1
We have used a set of markers newly assigned to the proximal portion of mouse chromosome 1 to characterize the chromosomal segment deleted in the splotch-retarded (Spr) mouse mutant. Among nine markers tested in the heterozygote Spr/+mouse, we have identified four genes, Vil, Des, Inha, and Akp-3, which map within the Spr deletion. The closest distal marker to the deletion is the Acrg gene, with the distal deletion breakpoint mapping within the 0.8-cM segment separating Akp-3 and Acrg. The most proximal gene to the Spr deletion is Tp1. The proximal deletion breakpoint maps within the 0.8-cM segment separating Tp1 and Vil. The minimum size of the Spr deletion would therefore be limited to 14 cM, the genetic distance between Vil and Akp-3. The maximum size of the Spr deletion is estimated to be 16 cM, the genetic distance between Tp1 and Acrg.
- McGill University Canada
Genetic Markers, Male, Heterozygote, Mice, Inbred C3H, Chromosome Mapping, Mice, Mutant Strains, Blotting, Southern, Mice, Phenotype, Chromosomes, Human, Pair 2, Mutation, Animals, Humans, Female, Chromosome Deletion
Genetic Markers, Male, Heterozygote, Mice, Inbred C3H, Chromosome Mapping, Mice, Mutant Strains, Blotting, Southern, Mice, Phenotype, Chromosomes, Human, Pair 2, Mutation, Animals, Humans, Female, Chromosome Deletion
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