MIC‐A Genotypes 4/5.1 and 9/9 Are Positively Associated with Type 1 Diabetes Mellitus in Brazilian Population
Copyright policy )MIC‐A Genotypes 4/5.1 and 9/9 Are Positively Associated with Type 1 Diabetes Mellitus in Brazilian Population
Abstract: The aim of our study was to evaluate the frequencies of MIC‐A alleles and genotypes in Brazilian patients with type 1 diabetes mellitus (T1DM) and healthy controls. MHC class I chain‐related gene‐A (MIC‐A) has been shown to be associated with susceptibility to T1DM in different populations. We analyzed the DNA samples from 86 patients and 201 healthy controls for MIC‐A by PCR amplification, and fragment sizes were determined in an ABI prism DNA sequencer. We found increased frequencies of two genotypes, MIC‐A 4/5.1 (pc= 0.006; OR, 6.1) and 9/9 (pc= 0.045; OR, 5.75), in our patients (mean diagnosis age, 11.70 years; SD, 8.86; mean age, 20.44 years; SD, 12.17) compared with the controls (median age, 26.41 years; SD, 8.87).
- Universidade de São Paulo Brazil
- UNIVERSIDADE DE SAO PAULO Brazil
- University of Bucharest Romania
Diabetes Mellitus, Type 1, Base Sequence, Genotype, Case-Control Studies, Genes, MHC Class I, Humans, DNA Primers
Diabetes Mellitus, Type 1, Base Sequence, Genotype, Case-Control Studies, Genes, MHC Class I, Humans, DNA Primers
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