Gene mapping within the T/t complex of the mouse. IV: The inverted MHC is intermingled with several t-lethal genes
Copyright policy )Gene mapping within the T/t complex of the mouse. IV: The inverted MHC is intermingled with several t-lethal genes
Using a combination of classical genetics, serology, and molecular genetics, we have mapped as many as possible of the MHC components in t haplotypes. Results indicate that the whole MHC is included in a simple inversion with the relative positions of its genes being intact. Furthermore, some of the t-lethal mutations map very near to, or are intermingled with, components of the MHC. At the centromeric end the t12 lethal maps between TL and H-2D in the Qa region, and distally the tw5 lethal is inseparable from H-2K.
- Memorial Sloan Kettering Cancer Center United States
- Cornell University United States
Cytotoxicity, Immunologic, Male, Recombination, Genetic, Genetic Linkage, Immune Sera, H-2 Antigens, Chromosome Mapping, Nucleic Acid Hybridization, Mice, Inbred Strains, DNA Restriction Enzymes, Major Histocompatibility Complex, Mice, Animals, Female, Genes, Lethal, Alleles
Cytotoxicity, Immunologic, Male, Recombination, Genetic, Genetic Linkage, Immune Sera, H-2 Antigens, Chromosome Mapping, Nucleic Acid Hybridization, Mice, Inbred Strains, DNA Restriction Enzymes, Major Histocompatibility Complex, Mice, Animals, Female, Genes, Lethal, Alleles
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