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Developmental Cell
Article
License: Elsevier Non-Commercial
Data sources: UnpayWall
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Developmental Cell
Article . 2002
License: Elsevier Non-Commercial
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Developmental Cell
Article . 2002 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
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Creation of a Sog Morphogen Gradient in the Drosophila Embryo

Authors: Shaila Srinivasan; Ethan Bier; Kay E. Rashka;

Creation of a Sog Morphogen Gradient in the Drosophila Embryo

Abstract

A variety of genetic evidence suggests that a gradient of Decapentaplegic (Dpp) activity determines distinct cell fates in the dorsal region of the Drosophila embryo, and that this gradient may be generated indirectly by an inverse gradient of the BMP antagonist Short gastrulation (Sog). It has been proposed that Sog diffuses dorsally from the lateral neuroectoderm where it is produced, and is cleaved and degraded dorsally by the metalloprotease Tolloid (Tld). Here we show directly that Sog is distributed in a graded fashion in dorsal cells and that Tld degradation limits the levels of Sog dorsally. In addition, we find that Dynamin-dependent retrieval of Sog acts in parallel with degradation by Tld as a dorsal sink for active Sog.

Keywords

Dynamins, Embryo, Nonmammalian, Tolloid-Like Metalloproteinases, Cell Membrane, Bone Morphogenetic Protein 1, GTP Phosphohydrolases, Bone Morphogenetic Proteins, Animals, Drosophila Proteins, Insect Proteins, Drosophila, Developmental Biology

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
95
Top 10%
Top 10%
Top 1%
hybrid