Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging
Copyright policy )Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging
Calcium (Ca2+) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs) and inositol 1,4,5--trisphosphate receptors (IP3Rs) are the majorCa2+ release channels (CRCs) on the endo/sarcoplasmic reticulum(ER/SR).RyR1 and RyR2 are the key isoforms in skeletal and cardiac muscle and are essential role in excitation--contraction(E--C) coupling. IP3R1 and IP3R2 are required for muscle and neuronal function. RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca2+ release. This review focuses on the roles of CRCs in heart, skeletal muscle, brain, and aging.
- University Federico II of Naples Italy
- Columbia University Libraries, Open Scholarship Services United States
- Columbia University Medical Center United States
- Columbia University United States
- Columbia University United States
Aging, 4, Intracellular Space, 610, Pathology, Humans, Inositol 1,4,5-Trisphosphate Receptors, Protein Isoforms, Muscle, Skeletal, Cognition in old age, 5-Trisphosphate Receptors, Brain, 600, Ryanodine Receptor Calcium Release Channel, Skeletal, Inositol 1, Sarcoplasmic Reticulum, Aging; Brain; Energy Metabolism; Humans; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Space; Muscle, Skeletal; Protein Isoforms; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum, Muscle, Calcium, Ryanodine--Receptors, Energy Metabolism, Cytology, Gerontology, Arrhythmia
Aging, 4, Intracellular Space, 610, Pathology, Humans, Inositol 1,4,5-Trisphosphate Receptors, Protein Isoforms, Muscle, Skeletal, Cognition in old age, 5-Trisphosphate Receptors, Brain, 600, Ryanodine Receptor Calcium Release Channel, Skeletal, Inositol 1, Sarcoplasmic Reticulum, Aging; Brain; Energy Metabolism; Humans; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Space; Muscle, Skeletal; Protein Isoforms; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum, Muscle, Calcium, Ryanodine--Receptors, Energy Metabolism, Cytology, Gerontology, Arrhythmia
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).179 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!