TRPM2 Functions as a Lysosomal Ca2+-Release Channel in β Cells
TRPM2 Functions as a Lysosomal Ca2+-Release Channel in β Cells
TRPM2-mediated Ca2+release from lysosomal stores contributes to pancreatic β cell death in response to oxidative stress.
- National Oceanic and Atmospheric Administration United States
- The Ohio State University United States
- Nationwide Children's Hospital United States
- University of Hawaii at Manoa United States
- The Research Institute at Nationwide Children's Hospital United States
Mice, Knockout, Adenosine Diphosphate Ribose, Membrane Glycoproteins, Microscopy, Confocal, Dose-Response Relationship, Drug, Fluorescent Antibody Technique, Apoptosis, Hydrogen Peroxide, ADP-ribosyl Cyclase 1, Cell Line, Membrane Potentials, Mice, Inbred C57BL, Mice, Cell Line, Tumor, Insulin-Secreting Cells, Animals, Humans, Calcium, Lysosomes, Cells, Cultured
Mice, Knockout, Adenosine Diphosphate Ribose, Membrane Glycoproteins, Microscopy, Confocal, Dose-Response Relationship, Drug, Fluorescent Antibody Technique, Apoptosis, Hydrogen Peroxide, ADP-ribosyl Cyclase 1, Cell Line, Membrane Potentials, Mice, Inbred C57BL, Mice, Cell Line, Tumor, Insulin-Secreting Cells, Animals, Humans, Calcium, Lysosomes, Cells, Cultured
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