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Nature
Article . 1982 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
Nature
Article . 1982
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Erythrocytes deficient in glycophorin resist invasion by the malarial parasite Plasmodium falciparum

Authors: David J. Weatherall; G. Pasvol; J. S. Wainscoat;

Erythrocytes deficient in glycophorin resist invasion by the malarial parasite Plasmodium falciparum

Abstract

It has been suggested that one of the main factors which determines host susceptibility to different malarial parasites is the interaction of their invasive forms, merozoites, with specific receptors on the red cell membrane1–3. Thus the Duffy blood group determinants may be involved in the entry of Plasmodium vivax but not of Plasmodium falciparum into human red cells. When analysing red cells deficient in various blood group antigens, Miller et al. noted3 that two samples of En(a−) cells showed a reduction of invasion by P. falciparum4. These cells lack both the major transmembrane sialoglycoprotein, glycophorin A (or MN glycoprotein), and the independently segregating Wrightb (Wrb) antigen and also show increased glycosylation of band 3, the major membrane-penetrating glycoprotein. Despite this, En(a−) individuals are haematologically normal5. We have now confirmed that En(a−) cells obtained fresh from three En(a−) individuals are indeed relatively resistant to invasion by P. falciparum although they are able to support parasite development. Our results also indicate that these cells may be a useful model in the search for a putative receptor for P. falciparum.

Related Organizations
Keywords

Erythrocytes, Sialoglycoproteins, Erythrocyte Membrane, Plasmodium falciparum, Antibodies, Monoclonal, Antigen-Antibody Complex, Blood Proteins, Anion Exchange Protein 1, Erythrocyte, Blood Group Antigens, Humans, Glycophorins

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Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
213
Top 10%
Top 1%
Top 1%