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Coronavirus Genomic-Sequence Variations and the Epidemiology of the Severe Acute Respiratory Syndrome

Authors: Stephen K W, Tsui; Stephen S C, Chim; Y M Dennis, Lo;

Coronavirus Genomic-Sequence Variations and the Epidemiology of the Severe Acute Respiratory Syndrome

Abstract

To the Editor: Our teaching hospital was the site of a major outbreak of the severe acute respiratory syndrome (SARS).1 We sequenced viral isolates cultured from clinical specimens from seven patients with SARS in this outbreak. The viral isolates were from passage 1 of the SARS coronavirus cultured in Vero cells.2 We obtained the complete genomic sequence of the virus cultured from the mother of the index patient in this hospital outbreak (isolate Su-10, GenBank accession number AY282752).1 The mother's symptoms had begun on March 5, 2003; she died on April 13, 2003. We also sequenced the spike glycoprotein gene . . .

Related Organizations
Keywords

Membrane Glycoproteins, Base Sequence, Molecular Sequence Data, Genome, Viral, Sequence Analysis, DNA, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Viral Envelope Proteins, Spike Glycoprotein, Coronavirus, Hong Kong, Humans, Female

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Powered by OpenAIRE graph
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
69
Top 10%
Top 1%
Top 1%