Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model
Copyright policy )Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model
Activin, a member of the transforming growth factor-β family, has been known to be a growth and differentiating factor. Despite its pluripotent effects, the roles of activin signaling in prostate cancer pathogenesis are still unclear. In this study, we established several cell lines that express a constitutive active form of activin type IB receptor (ActRIBCA) in human prostate cancer cells, ALVA41 (ALVA-ActRIBCA). There was no apparent change in the proliferation of ALVA-ActRIBCA cells in vitro; however, their migratory ability was significantly enhanced. In a xenograft model, histological analysis revealed that the expression of Snail, a cell-adhesion-suppressing transcription factor, was dramatically increased in ALVA-ActRIBCA tumors, indicating epithelial mesenchymal transition (EMT). Finally, mice bearing ALVA-ActRIBCA cells developed multiple lymph node metastases. In this study, we demonstrated that ActRIBCA signaling can promote cell migration in prostate cancer cells via a network of signaling molecules that work together to trigger the process of EMT, and thereby aid in the aggressiveness and progression of prostate cancers.
- Kyushu University Japan
Male, Epithelial-Mesenchymal Transition, Mice, Nude, Prostatic Neoplasms, Disease Models, Animal, Mice, Cell Movement, Cell Line, Tumor, Lymphatic Metastasis, Animals, Humans, Lymph Nodes, Snail Family Transcription Factors, Activin Receptors, Type I, Neoplasm Transplantation, Signal Transduction, Transcription Factors
Male, Epithelial-Mesenchymal Transition, Mice, Nude, Prostatic Neoplasms, Disease Models, Animal, Mice, Cell Movement, Cell Line, Tumor, Lymphatic Metastasis, Animals, Humans, Lymph Nodes, Snail Family Transcription Factors, Activin Receptors, Type I, Neoplasm Transplantation, Signal Transduction, Transcription Factors
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