Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice
Copyright policy )Deficient p75 low-affinity neurotrophin receptor expression exacerbates experimental allergic encephalomyelitis in C57/BL6 mice
We have investigated the role of p75NTR in inflammation in experimental allergic encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS). Induction of EAE in C57/BL6 wild-type mice resulted in expression of p75NTR in endothelial cells in the CNS. In contrast to the clinical manifestation of EAE observed in wild-type C57/BL6 mice, mice deficient for p75NTR (p75NTR knockout mice) developed severe or lethal disease and concomitant increased levels of inflammation in the CNS. Our findings suggest a physiological significant role for p75NTR in CNS endothelial cells during inflammation and involvement in preservation of blood-brain barrier integrity during a severe infiltrative attack.
- University of Groningen Netherlands
- Amsterdam University Medical Centers Netherlands
- Amsterdam UMC, location VUmc Netherlands
- Biomedical Primate Research Centre Netherlands
Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, CD3 Complex, Gene Expression, myelin oligodendrocyte glycoprotein, multiple sclerosis, Mice, MYELIN OLIGODENDROCYTE GLYCOPROTEIN, Animals, Glycoproteins, Probability, Mice, Knockout, CD11 Antigens, experimental allergic encephalomyelitis, NERVE GROWTH-FACTOR, DEATH, Endothelial Cells, BASIC-PROTEIN, Immunohistochemistry, Peptide Fragments, P75(NTR), Mice, Inbred C57BL, Disease Models, Animal, Microscopy, Electron, inflammation, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, CELLS, endothelial cell, Blood Vessels, Immunization, Myelin-Oligodendrocyte Glycoprotein, SPINAL-CORD, MESSENGER-RNA, SYSTEM
Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, CD3 Complex, Gene Expression, myelin oligodendrocyte glycoprotein, multiple sclerosis, Mice, MYELIN OLIGODENDROCYTE GLYCOPROTEIN, Animals, Glycoproteins, Probability, Mice, Knockout, CD11 Antigens, experimental allergic encephalomyelitis, NERVE GROWTH-FACTOR, DEATH, Endothelial Cells, BASIC-PROTEIN, Immunohistochemistry, Peptide Fragments, P75(NTR), Mice, Inbred C57BL, Disease Models, Animal, Microscopy, Electron, inflammation, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, CELLS, endothelial cell, Blood Vessels, Immunization, Myelin-Oligodendrocyte Glycoprotein, SPINAL-CORD, MESSENGER-RNA, SYSTEM
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