Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction
Copyright policy )Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction
Death-associated protein 3 (DAP3) is crucial for promoting apoptosis induced by various stimulations. This report demonstrates that DAP3 is also important for T cell receptor (TCR)-mediated apoptosis induction in immature thymocytes. Enforced expression of DAP3 accelerated the negative selection in developing thymocytes, using the reaggregate thymus organ culture system. In addition, expression of DAP3 accelerated TCR-mediated apoptosis induction in DO11.10 cells. We also demonstrated that DAP3 translocates into the nucleus during TCR-mediated apoptosis in a Nur77 dependent manner. It is concluded that DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77.
- Hokkaido Bunkyo University Japan
- Hokkaido University Japan
- University of Tokushima Japan
Cell Nucleus, 491, Active Transport, Cell Nucleus, Receptors, Antigen, T-Cell, Proteins, RNA-Binding Proteins, Apoptosis, Negative selection, Mice, Nur77, Nuclear Receptor Subfamily 4, Group A, Member 1, Death-associated protein 3, Animals, T cell receptor, Apoptosis Regulatory Proteins, Adaptor Proteins, Signal Transducing
Cell Nucleus, 491, Active Transport, Cell Nucleus, Receptors, Antigen, T-Cell, Proteins, RNA-Binding Proteins, Apoptosis, Negative selection, Mice, Nur77, Nuclear Receptor Subfamily 4, Group A, Member 1, Death-associated protein 3, Animals, T cell receptor, Apoptosis Regulatory Proteins, Adaptor Proteins, Signal Transducing
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