IL-13 Attenuates Vascular Tube Formation Via JAK2-STAT6 Pathway
Copyright policy )IL-13 Attenuates Vascular Tube Formation Via JAK2-STAT6 Pathway
Interleukin (IL)-13, which is a cytokine produced by type 2 helper T cells, has pathophysiological roles in allergic inflammation and fibrosis formation. IL-13 shares many functional properties with IL-4, which is known to inhibit angiogenesis.The effects of IL-13 on angiogenesis were examined using human coronary artery endothelial cells (HCAECs), in addition to investigating the mechanism(s) of this action. Using an in vitro assay of angiogenesis it was demonstrated that IL-13, as well as IL-4, significantly inhibited capillary-like tube formation. Migration of HCAECs, considered to be a process of new capillary tube formation, was also significantly inhibited by IL-13. IL-13 activated signal transduction and transcription 6 (STAT6) as a result of the activation of Janus kinase 2 (JAK2). The inhibitory effect of IL-13 on angiogenesis was abolished by depletion of JAK2 and STAT6 by RNA interference.IL-13 has anti-angiogenic activity as a result of activation of JAK2 and subsequent activation of STAT6.
- Saga University Japan
Interleukin-13, Interleukin-4 Receptor alpha Subunit, Neovascularization, Physiologic, Janus Kinase 2, Coronary Vessels, Interleukin-13 Receptor alpha1 Subunit, Receptors, Interleukin-4, Cell Movement, Humans, Interleukin-4, Phosphorylation, RNA, Small Interfering, STAT6 Transcription Factor, Cells, Cultured, Signal Transduction
Interleukin-13, Interleukin-4 Receptor alpha Subunit, Neovascularization, Physiologic, Janus Kinase 2, Coronary Vessels, Interleukin-13 Receptor alpha1 Subunit, Receptors, Interleukin-4, Cell Movement, Humans, Interleukin-4, Phosphorylation, RNA, Small Interfering, STAT6 Transcription Factor, Cells, Cultured, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).33 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!