Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein
Copyright policy )Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein
Mouse and human cDNA encoding AES (amino‐terminal enhancer of split) and ESG (enhancer of split groucho) proteins with strong similarity to Drosophila enhancer of split groucho protein were isolated and sequenced. Mouse AES‐1 and AES‐2 proteins, probably resulting from alternative splicing, contain 202 and 196 amino acids, respectively, while mouse ESG protein consists of 771 amino acids. The amino acid sequences of mouse and human AES proteins were found to exhibit approximately 50% identity to the amino‐terminal region of Drosophila groucho, mouse ESG and human transducin‐like enhancer of split (TLE) proteins. Mouse AES transcripts of 1.5 kb and 1.2 kb were abundantly expressed in muscle, heart and brain. Human AES transcripts of 1.6 kb and 1.4 kb were predominantly present in muscle, heart and placenta. Mouse ESG (homolog of human TLE 3) transcripts of 3.3 kb and 4.0 kb were found only in testis, while human TLE 1 transcripts of 4.5 kb was more abundant in muscle and placenta compared to heart, brain, lung, liver, kidney and pancreas. Human AES, TLE 1 and TLE 3 genes were mapped to chromosomes 19, 9 and 15, respectively, using human and Chinese hamster hybrid cell lines.
- National Institutes of Health United States
- National Institute of Health Pakistan
- Research Triangle Park Foundation United States
- National Institute of Environmental Health Sciences United States
- National Institutes of Health Malaysia
Male, Chromosomes, Human, Pair 15, Base Sequence, Molecular Sequence Data, Chromosome Mapping, DNA, Hybrid Cells, Blotting, Northern, DNA-Binding Proteins, Mice, Organ Specificity, Animals, Humans, Drosophila, Female, Amino Acid Sequence, Cloning, Molecular, Chromosomes, Human, Pair 9, Poly A, Chromosomes, Human, Pair 19
Male, Chromosomes, Human, Pair 15, Base Sequence, Molecular Sequence Data, Chromosome Mapping, DNA, Hybrid Cells, Blotting, Northern, DNA-Binding Proteins, Mice, Organ Specificity, Animals, Humans, Drosophila, Female, Amino Acid Sequence, Cloning, Molecular, Chromosomes, Human, Pair 9, Poly A, Chromosomes, Human, Pair 19
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